Art. -Nr.: HY-148785

Nimucitinib

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Nimucitinib is a selective JAK inhibitor with potent tear secretion-promoting activity. Nimucitinib downregulates relevant signal transduction pathways by inhibiting the catalytic activity of JAK family tyrosine kinases. Nimucitinib promotes tear secretion in rabbits and inhibits corneal injury in rats. Nimucitinib can be used in dry eye-related research.

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Reinheit: 99.27%
CAS. Nr.: 2740557-24-6
Formel: C₂₅H₂₆F₂N₆O₂
Molecular Weight:480.51

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Nimucitinib Chemical Structure

CAS. Nr.: 2740557-24-6

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle JAK Isoform-spezifische Produkte anzeigen :

In Vivo

Nimucitinib (0.001-0.01% solution; eye drop; single administration; 50 μL) promotes tear secretion in normal rabbits in a concentration-dependent manner^[1].
Nimucitinib (0.01% solution, administered via ocular instillation, 50 μL per dose, four times daily for 10 consecutive days) promotes tear secretion in a rabbit model of atropine-induced dry eye^[1].
Nimucitinib (0.003-0.01% solution; eye drop; 6 times per day for 11 consecutive days; 5 μL each time) inhibits corneal injury in a rat model of dry eye induced by extraorbital lacrimal gland excision^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

JW white rabbit (male, weight ~2 kg)^[1]
Dosage:

0.001% solution; 0.01% solution
Administration:

ocular instillation; single dose; 50 μL
Result:

Increased tear volume by 131% compared to pre-administration in the 0.001% solution group.
Increased tear volume by 168% compared to pre-administration in the 0.01% solution group.

Animal Model:

JW white rabbit (male, weight ~2 kg, atropine-induced dry eye model)^[1]
Dosage:

0.01% solution
Administration:

ocular instillation; 4 times daily; 10 days; 50 μL
Result:

Increased tear volume by 151% compared to pre-administration.

Animal Model:

SD rat (male, 6 weeks old, extraorbital lacrimal gland excision-induced dry eye model)^[1]
Dosage:

0.003% solution; 0.01% solution
Administration:

ocular instillation; 6 times daily; 11 days; 5 μL
Result:

Resulted in a corneal damage score of 13.0 in the 0.003% solution group.
Resulted in a corneal damage score of 10.5 in the 0.01% solution group.

Chemical Information

CAS. Nr. 2740557-24-6
Appearance Solid
Molecular Weight 480.51
Formel C₂₅H₂₆F₂N₆O₂
Color Off-white to light yellow
SMILES

FC1=CC(F)=CC(CNC2=CC(NC3=CC(NC([C@H]4CCCNC4)=O)=CC=C3)=NC=C2C(N)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (260.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0811 mL

10.4056 mL

20.8112 mL

5 mM

0.4162 mL

2.0811 mL

4.1622 mL

10 mM

0.2081 mL

1.0406 mL

2.0811 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kaneko Y, et al. Novel nicotinamide compounds and uses thereof. JP2025014078A. Japan Patent; 2025 Jan 29.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0811 mL	10.4056 mL	20.8112 mL	52.0281 mL
	5 mM	0.4162 mL	2.0811 mL	4.1622 mL	10.4056 mL
	10 mM	0.2081 mL	1.0406 mL	2.0811 mL	5.2028 mL
	15 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4685 mL
	20 mM	0.1041 mL	0.5203 mL	1.0406 mL	2.6014 mL
	25 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0811 mL
	30 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.7343 mL
	40 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL
	50 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0406 mL
	60 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8671 mL
	80 mM	0.0260 mL	0.1301 mL	0.2601 mL	0.6504 mL
	100 mM	0.0208 mL	0.1041 mL	0.2081 mL	0.5203 mL

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Nimucitinib

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Alle JAK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Nimucitinib

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Alle JAK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Nimucitinib Related Classifications

HY-148785 Related Classifications