Org-9935
Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM.
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- CAS. Nr.: 129425-83-8
- Formel: C15H16N2O3S
- Molecular Weight:304.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 129425-83-8
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Molecular Weight 304.36
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Formel C15H16N2O3S
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SMILES
O=C1CC(C)C(C2=CC3=CC(OC)=C(OC)C=C3S2)=NN1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Dent, G., et al., (1991). Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. British journal of pharmacology, 103(2), 1339-1346. [Content Brief]
[2]. El-Metwally, M., et al., (1997). The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European journal of pharmacology, 324(2-3), 227-232. [Content Brief]
[3]. Jensen, J. T., et al., (2008). The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception, 77(4), 303-307. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Org-9935 Related Classifications
HY-120029 Related Classifications
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