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Art. -Nr.: HY-135226

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PROLI NONOate

Name: PROLI NONOate
Brand: MedChemExpress
SKU: HY-135226
Price: 75.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.

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Reinheit : 98%
CAS. Nr.: 178948-42-0
Formel: C₅H₇N₃Na₂O₄
Molecular Weight:219.11

Speicherung:

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

PROLI NONOate Chemical Structure

CAS. Nr.: 178948-42-0

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Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll (1)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Chemical Information

CAS. Nr. 178948-42-0
Appearance Solid
Molecular Weight 219.11
Formel C₅H₇N₃Na₂O₄
Color White to off-white
SMILES

O=C(O[Na])[C@H]1N(/[N+]([O-])=N/O[Na])CCC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (456.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5639 mL

22.8196 mL

45.6392 mL

5 mM

0.9128 mL

4.5639 mL

9.1278 mL

10 mM

0.4564 mL

2.2820 mL

4.5639 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Protokoll

All Animals and Diseases

Protocol for Pharmacokinetic Study
Pharmacokinetic studies quantify how an organism handles a drug over time through absorption, distribution, metabolism, and excretion, and the core experimental readout is the concentration-time profile of parent drug and, when relevant, metabolites in biological matrices such as plasma, whole blood, urine, bile, or tissue. Pharmacokinetic analysis links dose, route, exposure, clearance, half-life, distribution, bioavailability, and systemic exposure to drug efficacy and toxicity hypotheses rather than measuring a signaling pathway directly. The literature links pharmacokinetics to drug-development phenotypes by showing that drug metabolism and pharmacokinetics influence compound progression, exposure-response interpretation, safety margins, dosing strategy, and failure risk during discovery and development. DMPK science contributes to compound optimization by integrating physicochemical properties, in vitro metabolism, transporter behavior, in vivo exposure, and pharmacodynamic contex

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Saavedra, et al. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J. Med. Chem. 39, 4361-4365 (1996).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.5639 mL	22.8196 mL	45.6392 mL	114.0979 mL
	5 mM	0.9128 mL	4.5639 mL	9.1278 mL	22.8196 mL
	10 mM	0.4564 mL	2.2820 mL	4.5639 mL	11.4098 mL
	15 mM	0.3043 mL	1.5213 mL	3.0426 mL	7.6065 mL
	20 mM	0.2282 mL	1.1410 mL	2.2820 mL	5.7049 mL
	25 mM	0.1826 mL	0.9128 mL	1.8256 mL	4.5639 mL
	30 mM	0.1521 mL	0.7607 mL	1.5213 mL	3.8033 mL
	40 mM	0.1141 mL	0.5705 mL	1.1410 mL	2.8524 mL
	50 mM	0.0913 mL	0.4564 mL	0.9128 mL	2.2820 mL
	60 mM	0.0761 mL	0.3803 mL	0.7607 mL	1.9016 mL
	80 mM	0.0570 mL	0.2852 mL	0.5705 mL	1.4262 mL
	100 mM	0.0456 mL	0.2282 mL	0.4564 mL	1.1410 mL

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll
Reinheit & Dokumentation
Verweise

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PROLI NONOate

Biologische Aktivität

Beschreibung

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PROLI NONOate Related Classifications

HY-135226 Related Classifications

Bioz

Keywords

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