Promiximab
Promiximab is a humanized anti-CD56 IgG1 monoclonal antibody with a Kd value of 0.78 pM against the human target. Promiximab specifically binds to CD56-positive small cell lung cancer (SCLC) cells, possesses antiproliferative activity, and induces tumor regression. Promiximab serves as the antibody component of the antibody-drug conjugates Promiximab-DUBA and Promiximab-MMAE. Promiximab can be used in studies related to small cell lung cancer.
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- CAS. Nr.: 2924882-34-6
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H526 | IC50 |
> 300 nM
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Inhibition of cell viability against human NCI-H526 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
Inhibition of cell viability against human NCI-H526 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
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29435172 |
| NCI-H524 | IC50 |
> 300 nM
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Inhibition of cell viability against human NCI-H524 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
Inhibition of cell viability against human NCI-H524 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
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29435172 |
| NCI-H69 | IC50 |
> 300 nM
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Inhibition of cell viability against human NCI-H69 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
Inhibition of cell viability against human NCI-H69 small cell lung cancer cells assessed by CCK-8 assay after 72 hrs exposure.
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29435172 |
In Vitro
Promiximab (0.02-1200 nM; 72 h) does not inhibit the viability of CD56-expressing small cell lung cancer (SCLC) cell lines NCI-H526, NCI-H524, NCI-H69, or human NK cells at concentrations up to 1200 nM[1].
Promiximab (1 μg/mL; 30 min) specifically binds to CD56-expressing small cell lung cancer (SCLC) cell lines NCI-H526, NCI-H524 and NCI-H69, but does not bind to CD56-negative SCLC cell lines NCI-H446 and NCI-H128[1].
Promiximab (1 μg/mL; 4 h) binds to both glycosylated and deglycosylated CD56 ECD, and cross-reacts with human CD56-expressing cells[1].
Promiximab (10 μg/mL; 30 min, 3 h) is efficiently internalized into CD56-expressing small cell lung cancer (SCLC) cell lines NCI-H526, NCI-H524 and NCI-H69[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SCLC cell lines NCI-H526, NCI-H524, NCI-H69, human NK cells
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Concentration:0.02, 0.07, 0.29, 1.17, 4.69, 18.75, 75, 300, 1200 nM
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Incubation Time:72 h
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Result:Showed no significant inhibitory effect on cell viability.
In Vivo
Promiximab (5-10 mg/kg; i.v.; every three days; 3 total doses) causes no visible histopathological toxicity to major organs in Balb/c mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c nude (female, 5-6 weeks old, subcutaneous xenograft model)[1]
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Dosage:10 mg/kg
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Administration:i.v.; every three days; 3 total doses
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Result:Allowed tumors to grow to approximately 2000 mm3 over the study period.
Maintained stable body weight throughout treatment.
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Animal Model:Balb/c[1]
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Dosage:5, 10 mg/kg
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Administration:i.v.; every three days; 3 total doses
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Result:Showed no obvious histopathological changes in heart, liver, spleen, lung, and kidney tissues compared to vehicle-treated controls.
Chemical Information
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CAS. Nr. 2924882-34-6
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Promiximab Related Classifications
HY-P992523 Related Classifications
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