PSMA-IN-2
PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice.
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- CAS. Nr.: 2946600-14-0
- Formel: C54H60N14O18S2
- Molecular Weight:1257.27
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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PSMA 1.07 nM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:22Rv1 xenograft models[1]
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Dosage:0.85 mg/kg
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Administration:Intravenous injection (i.v.)
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Result:Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms). Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
Chemical Information
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CAS. Nr. 2946600-14-0
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Molecular Weight 1257.27
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Formel C54H60N14O18S2
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SMILES
CN(C1=CC=C(C2=C3N=S=NC3=C(C4=NSN=C42)C5=CC=C(C=C5)N(C)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C6=O)=C(C6=O)O)=O)C(O)=O)=O)C=C1)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PSMA-IN-2 Related Classifications
HY-149298 Related Classifications
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