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Art. -Nr.: HY-156458A

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(R)-SR-29065

(R)-SR-29065 is a selective REV-ERBα inhibitor with a IC₅₀ of 10 nM. (R)-SR-29065 is applicable to research related to autoimmune diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2756883-91-5
Formel: C₂₄H₂₄F₆N₂O₂S
Molecular Weight:518.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(R)-SR-29065 Chemical Structure

CAS. Nr.: 2756883-91-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(R)-SR-29065 is a selective REV-ERBα inhibitor with a IC₅₀ of 10 nM. (R)-SR-29065 is applicable to research related to autoimmune diseases^[1].

IC₅₀ & Target^[1]

REV-ERBα

10 nM (IC₅₀)

In Vitro

(R)-SR-29065 (Compound 2) (2 h) promotes the recruitment of SMRT corepressor peptide to purified human REV-ERBα, with an EC₅₀ of 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2756883-91-5
Molecular Weight 518.51
Formel C₂₄H₂₄F₆N₂O₂S
SMILES

O=S(N[C@H](C1=CN(CC(C)C)C2=CC(C3=C(C=CC=C3)C(F)(F)F)=CC=C12)C(F)(F)F)(C4CC4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. He Y, et al. Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders. J Med Chem. 2023;66(21):14815-14823. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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