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Art. -Nr.: HY-131502

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Taspine

Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage.

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CAS. Nr.: 602-07-3
Formel: C₂₀H₁₉NO₆
Molecular Weight:369.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Taspine Chemical Structure

CAS. Nr.: 602-07-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle P2X Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	11.2 μM Compound: 1	Antiproliferative activity against human A431 cells abnormally expressing EGFR after 48 hrs by MTT assay Antiproliferative activity against human A431 cells abnormally expressing EGFR after 48 hrs by MTT assay	[PMID: 20304537]
A549	IC₅₀	4.18 μM Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 20304537]
A549	IC₅₀	4.18 nM Compound: 1	Antiproliferative activity against human A549 cells Antiproliferative activity against human A549 cells	[PMID: 20006929]
Caco-2	IC₅₀	153 μM Compound: 1	Antiproliferative activity against human Caco-2 cells after 48 hrs by MTT assay Antiproliferative activity against human Caco-2 cells after 48 hrs by MTT assay	[PMID: 20304537]
Caco-2	IC₅₀	153 nM Compound: 1	Antiproliferative activity against human Caco-2 cells Antiproliferative activity against human Caco-2 cells	[PMID: 20006929]
ECV-304	IC₅₀	22.3 μM Compound: 1	Antiproliferative activity against human ECV304 cells after 48 hrs by MTT assay Antiproliferative activity against human ECV304 cells after 48 hrs by MTT assay	[PMID: 20304537]
ECV-304	IC₅₀	22.3 nM Compound: 1	Antiproliferative activity against human ECV304 cells Antiproliferative activity against human ECV304 cells	[PMID: 20006929]
HEK293	IC₅₀	15.95 μM Compound: 1	Antiproliferative activity against human HEK293 cells overexpressing EGFR after 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells overexpressing EGFR after 48 hrs by MTT assay	[PMID: 20304537]

Chemical Information

CAS. Nr. 602-07-3
Appearance Solid
Molecular Weight 369.37
Formel C₂₀H₁₉NO₆
Color White to off-white
SMILES

O=C1C2=CC=C(OC)C(O3)=C2C4=C(C3=O)C(CCN(C)C)=CC(OC)=C4O1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Izzuddin Bin Nadzirin, et al. Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition. Br J Pharmacol. 2021 Dec;178(24):4859-4872. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Taspine

Alle P2X Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Taspine Related Classifications

HY-131502 Related Classifications