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Art. -Nr.: HY-D3387

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TBI

TBI is a fluorescence enhancer with a K_d of 71 nM for the Broccoli fluorogenic RNA aptamer. TBI binds to the Broccoli fluorogenic RNA aptamer to activate its fluorescence.TBI undergoes photobleaching of its trans form, which dissociates rapidly, while cis-TBI from the media replaces the dissociated fluorophore to enable fluorophore recycling.TBI enables enhanced fluorescence of Broccoli during continuous cellular imaging (Ex/Em = 485/527 nm).

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CAS. Nr.: 3053266-55-7
Formel: C₁₈H₁₂F₂N₄O₂S
Molecular Weight:386.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TBI Chemical Structure

CAS. Nr.: 3053266-55-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

TBI (0.5 μM) binds purified Broccoli RNA to produce a complex with a red-shifted excitation spectrum, high quantum yield, and more than 13,000-fold fluorescence enhancement relative to free TBI^[1].
TBI binds purified Broccoli RNA with high affinity, having a K_d of 71 nM, comparable to BI and significantly higher than DFNS^[1].
TBI (10 μM; 1 h) exhibits low background fluorescence in HEK293T cells and induces high fluorescence specifically in cells expressing the Broccoli RNA aptamer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 3053266-55-7
Molecular Weight 386.38
Formel C₁₈H₁₂F₂N₄O₂S
SMILES

O=C(/C(NC1=S)=C/C2=CC(F)=C(C(F)=C2)O)N1CC3=C4C(N=CN4)=CC=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li X, et al. Engineering Fluorophore Recycling in a Fluorogenic RNA Aptamer. Angew Chem Int Ed Engl. 2021;60(45):24153-24161. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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