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Art. -Nr.: HY-108845

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Biologically Validated

Tenecteplase

Name: Tenecteplase
Brand: MedChemExpress
SKU: HY-108845
Price: 750.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: TNK-tPA)

Kundenbewertung

Based on 1 Customer Validation

Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 95.00%
CAS. Nr.: 191588-94-0
Molecular Weight:59.74 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tenecteplase Chemical Structure

CAS. Nr.: 191588-94-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-108865
Alteplase

Plasminogen Activator

Biologische Aktivität
- Beschreibung
- MCE Validation Data
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MCE Validation Data

≥ 90%, as determined by reducing SDS-PAGE.

In Vitro

Tenecteplase exhibits relatively slight cytotoxicity to neuronal cells compared to its parent compound Alteplase (HY-108865)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tenecteplase (0.25-2.5 mg/kg, iv, single dose) reduces infarct volume when administered in the first 30 minutes, ameliorates thrombin-induced ischemic thromboembolism in mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse ischemic thromboembolic models^[3].
Dosage:

0.25-2.5 mg/kg
Administration:

iv, single dose
Result:

Reduced infarct volume.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 191588-94-0
Appearance Liquid
Molecular Weight 59.74 kDa
Color Colorless to light yellow
SMILES

[Tenecteplase]
Synonyms

TNK-tPA
Versand

Shipping with dry ice.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kvistad CE, et al. Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial. Lancet Neurol. 2022 Jun;21(6):511-519. [Content Brief]

[2]. Thelengana A, et al. Tenecteplase versus alteplase in acute ischemic stroke: systematic review and meta-analysis[J]. Acta Neurologica Belgica, 2019, 119: 359-367. [Content Brief]

[3]. Correa-Paz C, et al., Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke. J Cereb Blood Flow Metab. 2024 Aug;44(8):1306-1318. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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