TRAM-39
Based on 1 Customer Validation
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.66%
- CAS. Nr.: 197525-99-8
- Formel: C20H14ClN
- Molecular Weight:303.78
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Membrane Receptor-targeted Compound Library
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Highly Selective Inhibitors Library
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Ion Channel Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Membrane Transporter/Ion Channel Compound Library
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Biologische Aktivität
IC50: 60 nM (KCa3.1 channel)[4]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
2.2 μM
Compound: 22
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Mitogen-induced cell proliferation assay to evaluate the antiproliferative effect in NIH 3T3 cells
Mitogen-induced cell proliferation assay to evaluate the antiproliferative effect in NIH 3T3 cells
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[PMID: 14698156] |
TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells[2]. TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 197525-99-8
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Appearance Solid
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Molecular Weight 303.78
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Formel C20H14ClN
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Color Off-white to light yellow
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SMILES
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (164.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Davies PJ, et al. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Auton Neurosci. 2006 Jan 30;124(1-2):26-30. [Content Brief]
[2]. Burnham MP, et al. Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br J Pharmacol. 2006 Jun;148(4):434-41. [Content Brief]
[3]. Ayabe T, et al. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1;277(5):3793-800. [Content Brief]
[4]. Wulff H, et al. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2919 mL | 16.4593 mL | 32.9186 mL | 82.2964 mL |
| 5 mM | 0.6584 mL | 3.2919 mL | 6.5837 mL | 16.4593 mL | |
| 10 mM | 0.3292 mL | 1.6459 mL | 3.2919 mL | 8.2296 mL | |
| 15 mM | 0.2195 mL | 1.0973 mL | 2.1946 mL | 5.4864 mL | |
| 20 mM | 0.1646 mL | 0.8230 mL | 1.6459 mL | 4.1148 mL | |
| 25 mM | 0.1317 mL | 0.6584 mL | 1.3167 mL | 3.2919 mL | |
| 30 mM | 0.1097 mL | 0.5486 mL | 1.0973 mL | 2.7432 mL | |
| 40 mM | 0.0823 mL | 0.4115 mL | 0.8230 mL | 2.0574 mL | |
| 50 mM | 0.0658 mL | 0.3292 mL | 0.6584 mL | 1.6459 mL | |
| 60 mM | 0.0549 mL | 0.2743 mL | 0.5486 mL | 1.3716 mL | |
| 80 mM | 0.0411 mL | 0.2057 mL | 0.4115 mL | 1.0287 mL | |
| 100 mM | 0.0329 mL | 0.1646 mL | 0.3292 mL | 0.8230 mL |
TRAM-39 Related Classifications
HY-103308 Related Classifications
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