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Art. -Nr.: HY-189696

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XDTM13

XDTM13 is a biphenyl amide small-molecule TMPRSS2 inhibitor derived from the lead scaffold Avoralstat (HY-16735), with an IC₅₀ of 3.60 nM. XDTM13 inhibits the autoproteolytic cleavage of TMPRSS2 protein in prostate cancer LNCaP cells and suppresses the migration and invasion ability of LNCaP cells. XDTM13 can be used for research on prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₉H₃₀N₆O₅
Molecular Weight:542.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

XDTM13 Chemical Structure

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Preis

Verfügbarkeit

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

OthersAnti-cancer

Others

XDTM13 inhibits TMPRSS2 in a fluorescence-based substrate assay with an IC₅₀ of 3.60 nM; its half-life in human liver microsomes is 578 min, with an intrinsic clearance of 2.40 μL/min/mg^[1].
XDTM13 (100 μM; 24 h) blocks TMPRSS2 autoproteolysis in LNCaP cells, increasing full-length TMPRSS2 and reducing its cleaved N-terminal fragment^[1].

Anti-cancer

XDTM13 (25-100 μM; 72 h) reduced LNCaP cell viability at 100 μM, but not at 25 μM^[1].
XDTM13 (25-100 μM; 0-48 h) inhibits LNCaP cell migration and invasion in transwell assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

LNCaP
Concentration:

25, 100 μM
Incubation Time:

72 h
Result:

Showed no significant reduction in LNCaP cell viability at 25 μM, yet triggered pronounced viability suppression at 100 μM.

Western Blot Analysis^[1]

Cell Line:

LNCaP
Concentration:

100 μM
Incubation Time:

24 h
Result:

Resulted in a marked increase in the uncleaved, full-length TMPRSS2 band and a corresponding decrease in the cleaved N-terminal fragment.
Exhibited substantially stronger inhibition of TMPRSS2 autoproteolysis than the other tested compounds.

Cell Migration Assay ^[1]

Cell Line:

LNCaP
Concentration:

25, 100 μM
Incubation Time:

48 h
Result:

Reduced migrated LNCaP cells at both 25 and 100 μM compared with control.
Was more effective than the comparator at inhibiting LNCaP cell migration.

Cell Invasion Assay^[1]

Cell Line:

LNCaP
Concentration:

25, 100 μM
Incubation Time:

48 h
Result:

Reduced invaded LNCaP cells at both 25 and 100 μM compared with control.
Was more effective than the comparator at inhibiting LNCaP cell invasion.

Cell Migration Assay ^[1]

Cell Line:

LNCaP
Concentration:

100 μM
Incubation Time:

0, 24, 48 h
Result:

Showed superior anti-migratory activity, with reduced wound closure at 24 and 48 h.

Related Protocols :

Chemical Information

Molecular Weight 542.59
Formel C₂₉H₃₀N₆O₅
SMILES

O=C(O)C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC=C(N4CCOCC4)C=C3C(NC5=CC=C(C(N)=N)C=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jin Z, et al. Discovery of Biaryl amide-containing transmembrane serine protease 2 (TMPRSS2) inhibitors for the treatment of prostate Cancer. Bioorganic chemistry. 2026 Sep 11;182:110515.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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