YM928
YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders.
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- CAS. Nr.: 190842-36-5
- Formel: C14H10ClN3OS
- Molecular Weight:303.77
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neuron | IC50 |
2 μM
Compound: 16i, YM928
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Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay
Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay
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[PMID: 25792143] |
Chemical Information
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CAS. Nr. 190842-36-5
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Molecular Weight 303.77
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Formel C14H10ClN3OS
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SMILES
O=C1N=C(SC2=NC=CC=C12)N(C)C3=CC=C(C=C3)Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
YM928 Related Classifications
HY-118814 Related Classifications
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