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Art. -Nr.: HY-147346

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Zelicapavir

Name: Zelicapavir
Brand: MedChemExpress
SKU: HY-147346
Price: 510.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: EDP-938; RSV-IN-7)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Zelicapavir (RSV-IN-7) (example 253) is an orally active RSV inhibitor (EC₅₀: < 0.4 μΜ).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.10%
CAS. Nr.: 2070852-76-3
Formel: C₂₇H₂₂F₃N₇O₃
Molecular Weight:549.50

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Zelicapavir Chemical Structure

CAS. Nr.: 2070852-76-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Zelicapavir (RSV-IN-7) (example 253) is an orally active RSV inhibitor (EC₅₀: < 0.4 μΜ)^[1].

IC₅₀ & Target

RSV^[1]

In Vitro

Zelicapavir inhibits RSV strains RSV-A Long, RSV-A2, RSV-A M37, RSV-B VR-955 in cells Hep-2, A549, Vero, HBEC, reduces the level of viral RNA in RSV-infected cells with EC₅₀s in nanomolar levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[2]

Cell Line:

Hep-2, A549, Vero, HBEC
Concentration:
Incubation Time:

6 days
Result:

Inhibited viral RNA levels.

In Vivo

Zelicapavir (100 mg/kg, po, twice a day for 6 days) reduces the viral load in the bronchoalveolar lavage (BAL) fluid, exhibits antiviral activity in RSV-infected african green monkey model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

RSV-infected african green monkey model^[2]
Dosage:

100 mg/kg
Administration:

po, twice a day for 6 days
Result:

Reduced the viral load in the bronchoalveolar lavage (BAL) fluid.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 2070852-76-3
Appearance Solid
Molecular Weight 549.50
Formel C₂₇H₂₂F₃N₇O₃
Color Light yellow to yellow
SMILES

FC(F)(C1=CC(N2CCOCC2)=C(C3=NN=C(N[C@H]4N=C(C5=CC=CC=C5)C6=CC=CC=C6NC4=O)O3)N=C1)F
Synonyms

EDP-938; RSV-IN-7
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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mBio

A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance. [Abstract]

2024 Sep 11;15(9):e0138524. PMID: 39162560

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (90.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8198 mL

9.0992 mL

18.1984 mL

5 mM

0.3640 mL

1.8198 mL

3.6397 mL

10 mM

0.1820 mL

0.9099 mL

1.8198 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shook Brian C., et al. Preparation of benzodiazepine derivatives for use as RSV inhibitors. Patent. WO2017015449 A1.

[2]. Rhodin MHJ, et al., EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. PLoS Pathog. 2021 Mar 15;17(3):e1009428. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8198 mL	9.0992 mL	18.1984 mL	45.4959 mL
	5 mM	0.3640 mL	1.8198 mL	3.6397 mL	9.0992 mL
	10 mM	0.1820 mL	0.9099 mL	1.8198 mL	4.5496 mL
	15 mM	0.1213 mL	0.6066 mL	1.2132 mL	3.0331 mL
	20 mM	0.0910 mL	0.4550 mL	0.9099 mL	2.2748 mL
	25 mM	0.0728 mL	0.3640 mL	0.7279 mL	1.8198 mL
	30 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5165 mL
	40 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1374 mL
	50 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9099 mL
	60 mM	0.0303 mL	0.1517 mL	0.3033 mL	0.7583 mL
	80 mM	0.0227 mL	0.1137 mL	0.2275 mL	0.5687 mL

Bioz

Keywords

Zelicapavir

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Zelicapavir

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