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Art. -Nr.: HY-151448

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ZIKV-IN-5

ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC₅₀=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase.

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CAS. Nr.: 3033697-92-3
Formel: C₃₆H₄₅NO₄Si
Molecular Weight:583.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ZIKV-IN-5 Chemical Structure

CAS. Nr.: 3033697-92-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC₅₀=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase^[1].

IC₅₀ & Target

EC50:0.71 μM (ZIKV)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	>200 μM Compound: 5c	Cytotoxicity against african green monkey Vero cells incubated for 96 hrs Cytotoxicity against african green monkey Vero cells incubated for 96 hrs	[PMID: 36055002]

In Vitro

ZIKV-IN-5 (0-200 μM; 96 h) shows low cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Vero cells
Concentration:

0-200 μM
Incubation Time:

96 h
Result:

Exhibited low cytotoxicities with a CC₅₀ value of more than 200 μM

Chemical Information

CAS. Nr. 3033697-92-3
Molecular Weight 583.83
Formel C₃₆H₄₅NO₄Si
SMILES

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@](C)(CO[Si](C4=CC=CC=C4)(C(C)(C)C)C5=CC=CC=C5)/C(CC[C@@]23C)=N/O)=C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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