Cancer
Cancer therapy has always been the focus of biomedical research and practice across the world. Cancer is a disease in which mutations or genomic changes enable cells to achieve a wide range of abilities in order to escape apoptosis and growth inhibition signals, resulting in unlimited cells growth and spread to other parts of the body. It is characterized by uncontrolled proliferation of abnormal cells and abnormal recognition of the immune system. There are different treatments for cancer, depending on its progress, the type of cancer, the types of treatments available, and the target of treatment. Surgery, chemotherapy (CT) and radiotherapy (RT) are the three main methods to treat cancer in the traditional way. However, these treatments are potentially toxic and may cause side effects and multidrug resistance. Although cancer therapy can prolong the life of patients, yet a large number of patients still die because of cancer recurrence, hence the research on cancer recurrence and metastasis has always been the focus in the field of clinical medicine. According to different nature of therapies, the types of cancer treatment can be divided into the following categories.
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Cancer Targeted Therapy (46172)
Cancer targeted therapy is the foundation of precision medicine; it uses drugs or other substances to target specific genes and proteins that control cancer cells’ growth, division and spreading. -
Cancer Immunotherapy (14370)
Cancer immunotherapy (CIT) is a type of biological therapy, aiming to improve anti-tumor immune responses with fewer off-target effects than chemotherapy. -
Cancer Stem Cells (3460)
Cancer stem cells (CSCs) are populations of cancer cells that have the properties of stem cells i.e. self-renewal and ability to generate differentiated progenies. -
Cancer Drug Resistance (2283)
Drug resistance in chemotherapy, radiotherapy, molecular targeted therapy and immunotherapy is one of the main causes of death due to cancer. -
Cancer Metabolism and Metastasis (53244)
Metabolic abnormalities are a major feature of cancer, such as increased substance anabolic pathways and aerobic glycolysis.
References:
- [1] Larsen BD, et al. Science. 2022; 376(6592):476-483.
- [2] Ushijima T, et al. Science. 2021; 373(6562):1474-1479.
- [3] Shen S, et al. Cell. 2020; 183(4):860-874.
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Cell Proliferation Compound Library3,708 compoundsHY-L201
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Cancer Stem Cells Compound Library3,590 compoundsHY-L135
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Anti-Brain Cancer Compound Library2,160 compoundsHY-L188
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Anti-Ovarian Cancer Compound Library3,022 compoundsHY-L173
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Anti-Gastric Cancer Compound Library1,230 compoundsHY-L184
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Anti-Cancer Compound Library11,280 compoundsHY-L025
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Anti-Cancer Metabolism Compound Library3,876 compoundsHY-L083
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Anti-Cancer Natural Product Library2,045 compoundsHY-L107
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Targeted Therapy Drug Library107 compoundsHY-L080
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Angiogenesis-Related Compound Library3,738 compoundsHY-L088
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Anti-Lung Cancer Compound Library3,121 compoundsHY-L075
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Anti-Breast Cancer Compound Library3,464 compoundsHY-L074
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Anti-Pancreatic Cancer Compound Library4,416 compoundsHY-L077
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Anti-Liver Cancer Compound Library3,056 compoundsHY-L101
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Anti-Colorectal Cancer Compound Library2,720 compoundsHY-L103
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FDA-Approved Anticancer Drug Library1,544 compoundsHY-L122
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Anti-Prostate Cancer Compound Library3,722 compoundsHY-L124
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Chemotherapy Drug Library155 compoundsHY-L112
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Tumorigenesis-Related Compound Library146 compoundsHY-L100