HCA-6
HCA-6 is a calcium-channel and P-glycoprotein blocker. HCA-6 can induce cancer cells apoptosis and increase anticancer activity of Cisplatin (HY-17394). HCA-6 also exhibits antibacterial activity against Bacillus subtilis. HCA-6 can be used for the research of cancer and infection, such as breast cancer.
For research use only. We do not sell to patients.
- Formula: C30H33FN4O14
- Molecular Weight:692.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
HCA-6 (2 μM, 24 h) significantly enhances the anticancer activity of Cisplatin (HY-17394) in 4T1, MDA-MB-231, HeLa, HepG2, and SW480 cells, reduces the IC50 of Cisplatin in HeLa cells to 3.65 μM and increases the inhibition rate by 61.21%[1].
HCA-6 (10 μM) inhibits P-glycoprotein (P-gp)-mediated efflux of rhodamine 123[1].
HCA-6 (10 μg/mL) induces apoptosis in Hela cells[1].
HCA-6 (0.25-1 mg/mL) exhibits antibacterial activity against Bacillus subtilis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 692.60
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Formula C30H33FN4O14
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SMILES
O[C@@H]1[C@H](O)[C@@H](COC(COC2=CC=C(C3C(C(OCC)=O)=C(C)NC(C)=C3C(OCC)=O)C=C2[N+]([O-])=O)=O)O[C@H]1N(C(N4)=O)C=C(F)C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HCA-6 Related Classifications
HY-179026 Related Classifications
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