HOE-288
HOE-288 is an orally active angiotensin-converting enzyme (ACE) inhibitor. HOE-288 can be used for the research of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 93231-79-9
- Formula: C27H38N2O5
- Molecular Weight:470.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HOE-288 (10 mg/kg, i.g., daily for 1 weeks) results in a marked inhibition of CE activity in the brain cortex, the hypothalamus, and in the brainstem in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93231-79-9
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Molecular Weight 470.60
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Formula C27H38N2O5
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SMILES
O=C(C1N(CC2(CC3CCC2CC3)C1)C(C(C)NC(CCC4=CC=CC=C4)C(OCC)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dennes RP, et al. Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze. Psychopharmacology (Berl). 1993;111(4):435-41. [Content Brief]
[2]. Gohlke P, et al. Inhibition of converting enzyme in brain tissue and cerebrospinal fluid of rats following chronic oral treatment with the converting enzyme inhibitors ramipril and Hoe 288. J Cardiovasc Pharmacol. 1989;14 Suppl 4:S32-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HOE-288 Related Classifications
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