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Cat. No.: HY-184029

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PF-7845yne

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway.

For research use only. We do not sell to patients.

CAS No.: 1020321-13-4
Formula: C₂₇H₂₇N₅O₃
Molecular Weight:469.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PF-7845yne Chemical Structure

CAS No.: 1020321-13-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway^[1].

In Vitro

PF-7845yne (0.1-10000 nM; 30 min) potently and selectively inhibits mouse brain membrane FAAH, mirroring the activity of its parent compound PF-7845, with no activity against MAGL or ABHD6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

PF-7845yne (0.01-12.5 mg/kg; i.p.; single dose) potently and selectively inhibits brain FAAH activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57Bl/6J mice^[1]
Dosage:

0.01; 0.05; 0.25; 1.25; 6.25; 12.5 mg/kg
Administration:

i.p.; single dose
Result:

Completely inhibited brain fatty acid amide hydrolase (FAAH) activity at doses as low as 0.05 mg/kg.
Confirmed complete selectivity toward FAAH in mouse brain membrane and soluble proteomes, with no detectable off-target labeling at any tested dose.

Chemical Information

CAS No. 1020321-13-4
Molecular Weight 469.53
Formula C₂₇H₂₇N₅O₃
SMILES

O=C(N1CC/C(CC1)=C\C2=CC(OC3=NC=C(C=C3)OCCCC#C)=CC=C2)NC4=NN=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Niphakis MJ, et al. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2012;3(5):418-426. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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