AZ11657312
AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased renal medullary perfusion, only in mice treated with angiotensin II. AZ11657312 improves tissue oxygenation by blocking P2X7R, especially in areas of the kidney that are underoxygenated. Administration of AZ11657312 increased sodium excretion up to sixfold while normalizing blood pressure.
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- CAS No.: 804561-22-6
- Formula: C26H35N3O3
- Molecular Weight:437.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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All Angiotensin Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 804561-22-6
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Molecular Weight 437.57
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Formula C26H35N3O3
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SMILES
O=C(CC12CC3CC(CC(C2)C3)C1)NC4=CC(C(N5CC6OC(C5)CNC6)=O)=CC=C4C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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