2. Neuronal Signaling
  3. Amyloid-β Cholinesterase (ChE)
  4. Aβ-IN-5

Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity.

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Aβ-IN-5 Chemical Structure

Aβ-IN-5 Chemical Structure

CAS No. : 2417977-65-0

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Aβ-IN-5 Related Antibodies

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Description

Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].

IC50 & Target

IC50: 1.32 μM (BuChE), 21.29 μM (AChE)[1]
In Vitro

Aβ-IN-5 (Compound e12) (25 μM) exhibits significant inhibition of Aβ aggregation with an inhibitory rate of 72%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ-IN-5 Related Antibodies
In Vivo

Aβ-IN-5 (Compound e12) (15 mg/kg; p.o.) restores learning and memory function and exhibits no acute toxicity in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

348.40

Formula

C21H20N2O3
CAS No.
SMILES

O=C(N(C1C)CCC2=C1NC3=C2C=CC=C3)/C=C/C4=CC=C(O)C(O)=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aβ-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ-IN-52417977-65-0Amyloid-βCholinesterase (ChE)β-amyloid peptideAβAbetaAlzheimer’s diseasePC12SH-SY5Yneuroprotective effectInhibitorinhibitorinhibit

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