BBMP
BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research.
For research use only. We do not sell to patients.
- CAS No.: 97120-13-3
- Formula: C12H11BrN2O3S
- Molecular Weight:343.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BBMP is effective in both swelling and membrane potential assays displaying pIC50 values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC50 of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 97120-13-3
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Molecular Weight 343.20
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Formula C12H11BrN2O3S
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SMILES
O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C
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Synonyms
5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BBMP Related Classifications
HY-108984 Related Classifications
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