2. Anti-infection
  3. Bacterial
  4. BDM91270

BDM91270 (compound 29) is an E. coli AcrAB-TolC efflux pump inhibitor with an EC90 of 0.6 μM for wild-type E. coli AcrB. BDM91270 can be used in the study of Escherichia coli drug resistance.

For research use only. We do not sell to patients.

BDM91270 Chemical Structure

BDM91270 Chemical Structure

CAS No. : 2892824-11-0

Size Price Stock Quantity
5 mg USD 230 In-stock
10 mg USD 375 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

BDM91270 Related Antibodies

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Description

BDM91270 (compound 29) is an E. coli AcrAB-TolC efflux pump inhibitor with an EC90 of 0.6 μM for wild-type E. coli AcrB. BDM91270 can be used in the study of Escherichia coli drug resistance[1].

IC50 & Target

EC90: 0.6 μM (AcrB)[1].
Molecular Weight

419.73

Formula

C17H21Cl3N4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=C(N2CCNCC2)N=CC(C(OC3=CC=CC(CN)=C3)=O)=C1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (119.12 mM; Need ultrasonic)

DMSO : 25 mg/mL (59.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3825 mL 11.9124 mL 23.8248 mL
5 mM 0.4765 mL 2.3825 mL 4.7650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% PBS

    Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3825 mL 11.9124 mL 23.8248 mL 59.5621 mL
5 mM 0.4765 mL 2.3825 mL 4.7650 mL 11.9124 mL
10 mM 0.2382 mL 1.1912 mL 2.3825 mL 5.9562 mL
15 mM 0.1588 mL 0.7942 mL 1.5883 mL 3.9708 mL
20 mM 0.1191 mL 0.5956 mL 1.1912 mL 2.9781 mL
25 mM 0.0953 mL 0.4765 mL 0.9530 mL 2.3825 mL
30 mM 0.0794 mL 0.3971 mL 0.7942 mL 1.9854 mL
40 mM 0.0596 mL 0.2978 mL 0.5956 mL 1.4891 mL
50 mM 0.0476 mL 0.2382 mL 0.4765 mL 1.1912 mL
H2O 60 mM 0.0397 mL 0.1985 mL 0.3971 mL 0.9927 mL
80 mM 0.0298 mL 0.1489 mL 0.2978 mL 0.7445 mL
100 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5956 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BDM91270 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDM912702892824-11-0BDM 91270BDM-91270BacterialE. coliresistancebacterialInhibitorinhibitorinhibit

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