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Art. -Nr.: HY-189055

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β-Glucuronidase-IN-6

β-Glucuronidase-IN-6 is an Escherichia coli β-glucuronidase (EcGUS) inhibitor with an IC₅₀ of 0.39 μM, K_i of 0.60 μM, selectivity over bovine liver β-glucuronidase, and oral effectiveness. β-Glucuronidase-IN-6 preferentially binds the enzyme-substrate complex, interacts with residues Asp163, Glu413, and Trp549 to stabilize the binding complex. β-Glucuronidase-IN-6 does not inhibit Escherichia coli growth and exhibits low cytotoxicity toward human epithelial cells. β-Glucuronidase-IN-6 attenuates irinotecan-induced weight loss, diarrhea, and colonic injury in mice. β-Glucuronidase-IN-6 can be used for the research of irinotecan-induced gastrointestinal toxicity.

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CAS. Nr.: 3132205-57-0
Formel: C₁₅H₁₂N₂O₂S₂
Molecular Weight:316.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Glucuronidase-IN-6 Chemical Structure

CAS. Nr.: 3132205-57-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

β-Glucuronidase-IN-6 (compound 3-5B) potently inhibits purified Escherichia coli β-glucuronidase with an IC₅₀ of 0.39 μM. It acts as a non-competitive inhibitor of purified Escherichia coli β-glucuronidase with a K_i value of 0.60 μM. It does not inhibit bovine liver β-glucuronidase, indicating its high selectivity for Escherichia coli β-glucuronidase^[1].
β-Glucuronidase-IN-6 binds to Escherichia coli β-glucuronidase with high affinity, with a predicted binding energy of -6.64 kcal·mol^-1, and exhibits specific interactions with the Asp163, Glu413 and Trp549 residues^[1].
β-Glucuronidase-IN-6 does not inhibit the growth of E. coli cultures and exhibits low cytotoxicity against human Caco-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

β-Glucuronidase-IN-6 (compound 3-5B) (1 mg/kg/d; p.o.; once daily; for 15 consecutive days) alleviates Irinotecan (HY-16562)-induced gastrointestinal toxicity in BALB/cJ mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3132205-57-0
Molecular Weight 316.40
Formel C₁₅H₁₂N₂O₂S₂
SMILES

O=C(C1=C(OC)C=C2C=CC=CC2=C1)SC3=NN=C(C)S3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Xu K, et al. Gut Bacterial β-Glucuronidase Blockade by 1,3,4-Thiadiazole-Containing Thioester Inhibitors Mitigates Irinotecan-Induced Gastrointestinal Toxicity. Journal of medicinal chemistry. 2026 Aug 13;69(15):18300-18314.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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