Biotin-PEG3-C3-NH2
Based on 1 Customer Validation
Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 183896-00-6
- Formula: C20H38N4O5S
- Molecular Weight:446.60
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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PEGs |
PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 183896-00-6
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Appearance Oil
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Molecular Weight 446.60
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Formula C20H38N4O5S
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Color Colorless to light yellow
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SMILES
NCCCOCCOCCOCCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
Methanol : ≥ 175 mg/mL (391.85 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
[2]. Park S, et al. One-step, aid-mediated method for modification of glass surfaces with N-hydroxysuccinimide esters and its application to the construction of microarrays for studies of biomolecular interactions. Bioconjug Chem. 2010 Jul 21;21(7):1246-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 2.2391 mL | 11.1957 mL | 22.3914 mL | 55.9785 mL |
| 5 mM | 0.4478 mL | 2.2391 mL | 4.4783 mL | 11.1957 mL | |
| 10 mM | 0.2239 mL | 1.1196 mL | 2.2391 mL | 5.5979 mL | |
| 15 mM | 0.1493 mL | 0.7464 mL | 1.4928 mL | 3.7319 mL | |
| 20 mM | 0.1120 mL | 0.5598 mL | 1.1196 mL | 2.7989 mL | |
| 25 mM | 0.0896 mL | 0.4478 mL | 0.8957 mL | 2.2391 mL | |
| 30 mM | 0.0746 mL | 0.3732 mL | 0.7464 mL | 1.8660 mL | |
| 40 mM | 0.0560 mL | 0.2799 mL | 0.5598 mL | 1.3995 mL | |
| 50 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 60 mM | 0.0373 mL | 0.1866 mL | 0.3732 mL | 0.9330 mL | |
| 80 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL | 0.6997 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2239 mL | 0.5598 mL |
Biotin-PEG3-C3-NH2 Related Classifications
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