Biotin-PEG3-C3-NH2 

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH₂ functional group, that can be used in the synthesis of PROTACs^[1].

PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively^[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts^[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.60

C₂₀H₃₈N₄O₅S

183896-00-6

Oil

Colorless to light yellow

NCCCOCCOCCOCCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.  [Content Brief]

  [2]. Park S, et al. One-step, aid-mediated method for modification of glass surfaces with N-hydroxysuccinimide esters and its application to the construction of microarrays for studies of biomolecular interactions. Bioconjug Chem. 2010 Jul 21;21(7):1246-53.  [Content Brief]