BMS-687453 (Standard)
BMS-687453 (Standard) is the analytical standard of BMS-687453 (HY-10678). This product is intended for research and analytical applications. BMS-687453 is a potent and selective PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.
For research use only. We do not sell to patients.
- CAS No.: 1000998-59-3
- Formula: C22H21ClN2O6
- Molecular Weight:444.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-10838
GW 501516PPARδ Agonist -
HY-B0637
BezafibratePPAR Agonist -
HY-13956
PioglitazonePPARγ Agonist -
HY-B0664
CiprofibratePeroxisome Proliferator -
HY-17618
PemafibratePPARα Agonist -
HY-10678
BMS-687453 -
HY-13861
GW7647PPAR Agonist -
HY-17356
Fenofibrate -
HY-17386
RosiglitazonePPARγ Agonist -
HY-50935
TroglitazonePPARγ Agonist -
HY-16578
GW9662PPARγ Antagonist -
HY-13928
GW0742PPAR Agonist
Biological Activity
Description
IC50 & Target
EC50: 10 nM (GAL4-human PPARα), 4100 nM (GAL4-human PPARγ)[1]
IC50: 260 nM (Human PPARα), >15000 nM (Human PPARγ)[1]
Chemical Information
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CAS No. 1000998-59-3
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Molecular Weight 444.86
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Formula C22H21ClN2O6
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SMILES
ClC(C=C1)=CC=C1C2=NC(COC3=CC=CC(CN(C(OC)=O)CC(O)=O)=C3)=C(C)O2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Li J, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53(7):2854-64. [Content Brief]
[2]. Mukherjee R, et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26. [Content Brief]
[3]. Vassallo JD, et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111(2):402-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-687453 (Standard) Related Classifications
HY-10678R Related Classifications
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