BNTX maleate  (Synonyms: 7-Benzylidenenaltrexone maleate)

BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the K_is of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity^[1][2].

545.58

C₃₁H₃₁NO₈

864461-31-4

Solid

White to off-white

O[C@@]1(C/C2=C\C3=CC=CC=C3)[C@]4([C@@](C2=O)([H])OC5=C6O)C5=C(C=C6)C[C@@]1([H])N(CC7CC7)CC4.OC(/C=C\C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Portoghese PS, et al. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur J Pharmacol. 1992;218(1):195-196.  [Content Brief]

  [2]. House RV, et al. Suppression of immune function by non-peptidic delta opioid receptor antagonists. Neurosci Lett. 1995 Sep 29;198(2):119-22.  [Content Brief]

  [3]. Miyata Y, et al. Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4710-2.  [Content Brief]