Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

  • Bioorg Med Chem Lett. 2011 Aug 15;21(16):4710-2. doi: 10.1016/j.bmcl.2011.06.085.
Yoshinori Miyata  1 ,  Hideaki Fujii ,  Yumiko Osa ,  Seiki Kobayashi ,  Tsutomu Takeuchi ,  Hiroshi Nagase
Affiliations
  • 1. School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan.
PMID: 21764311 DOI: 10.1016/j.bmcl.2011.06.085
Abstract

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five Opioid Receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ(1) receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.

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