BTK-IN-19
BTK-IN-19 (Compound 51) is a reversible BTK inhibitor with an IC50 of <0.001 μM.
For research use only. We do not sell to patients.
- CAS No.: 1374240-01-3
- Formula: C21H22Cl2N6O
- Molecular Weight:445.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: <0.001 μM (BTK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
0.08 μM
Compound: 51
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Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
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[PMID: 36538993] |
BTK-IN-19 (Compound 51) inhibits B cell proliferation with IC50 of 0.080 μM (3 d)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B cells enriched from PBMC
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Concentration:
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Incubation Time:3 days
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Result:Inhibited B-cell proliferation with an IC50 of 0.080 μM.
BTK-IN-19 (5 mg/kg; p.o.) demonstrates low-moderate in vivo clearance and modest oral exposure (%F > 34) in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 mice[1]
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Dosage:80 mg/kg
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Administration:IP, once
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Result:Demonstrated strong inhibition of CD69.
Chemical Information
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CAS No. 1374240-01-3
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Molecular Weight 445.34
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Formula C21H22Cl2N6O
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SMILES
ClC1=CC(Cl)=CC(NCC(N2C[C@]3([H])N(C4=C5C(NC=C5)=NC=N4)CC[C@]3([H])CC2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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