SHMT Activator
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YP200
0 ImagesCat. No.: HY-191092YP200 is a potent and selective HDAC11 inhibitor (IC50 0.058 μM). YP200 stabilizes SHMT2 and induces SHMT2 protein accumulation. YP200 induces Apoptosis and G0/G1 cell cycle arrest. YP200 does not affect the levels of acetylated α-tubulin or acetylated histone H3. YP200 reduces the expression of Ki67 and Cyclin D1 in tumor tissues. YP200 can be used for research on non-small cell lung cancer (NSCLC).
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HDAC11-IN-5
0 ImagesCat. No.: HY-182019Purity: 98.25%HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC50 of 0.021 μM. HDAC11-IN-5 increases fatty acylation levels of substrate SHMT2 in AML cells. HDAC11-IN-5 induces apoptosis, G1 phase cell cycle arrest, ferroptosis, ROS production and terminal myeloid differentiation in AML cells. HDAC11-IN-5 demonstrates anti-tumor potency in an MLL-AF9-induced mouse AML model. HDAC11-IN-5 can be used for the research of cancer, such as acute myeloid leukemia.
