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Cat. No.: HY-176131

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AMX5160

AMX5160 (36) is an orally active BTK inhibitor, with an IC₅₀ of 0.98 nM against mutant BTK^C481S. AMX5160 (36) can be used in the research for leukemia, lymphoma, multiple sclerosis, and other autoimmune diseases.

For research use only. We do not sell to patients.

CAS No.: 2639293-95-9
Formula: C₂₈H₂₇ClN₄O₃
Molecular Weight:502.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AMX5160 Chemical Structure

CAS No.: 2639293-95-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

AMX5160 possesses IC₅₀ values of 93.2 nM and 85.85 nM in TMD8 and Ba/F3-BTK-C481S cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	Plasma Concentration	AUC	T_1/2	Clearance (CL)	V_d	T_max	Bioavailability
Mice^[1]	1 mg/kg	i.v.	2090±229 ng/mL	4229±742 ng·h/mL	3.55±0.17 h	4.01±0.76 mL/min/kg	0.66 L/kg	/	/
Mice^[1]	10 mg/kg	p.o.	1580±427 ng/mL	14146±5297 ng·h/mL	2.51±0.06 h	/	/	2 h	33.4%

In Vivo

AMX5160 (36; NIH/3T3-FL-BTK-C481S xenograft BALB/c nude mouse; 10, 25, 75 mg/kg; PO; bid) significantly inhibits tumor growth in a dose dependent manner. The tumor growth inhibition (TGI) is 58%, 63%, and 82% at doses of 10, 25, and 75 mg/kg, respectively. AMX5160 (36) was well tolerated in mice at higher doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2639293-95-9
Molecular Weight 502.99
Formula C₂₈H₂₇ClN₄O₃
SMILES

ClC1=CC(OC2=CC=CC=C2)=CC=C1C(C3=CNC4=NC=CC(N[C@H](CC5)CC[C@H]5NC(C)=O)=C34)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Debasis Das, et al. Discovery of Reversible, Noncovalent Bruton’s Tyrosine Kinase Inhibitors Targeting BTK C481S Mutation. ACS Med. Chem. Lett. 2025.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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