DNMT1-IN-5
DNMT1-IN-5 (Compound 55) is the inhibitor for DNMT that inhibits DNMT1 and DNMT3A with IC50 of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC50s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models.
For research use only. We do not sell to patients.
- CAS No.: 2982511-19-1
- Formula: C24H32FN7
- Molecular Weight:437.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA Methyltransferase Isoforms
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Biological Activity
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DNMT1 2.42 μM (IC50) |
DNMT3A 14.4 μM (IC50) |
Chemical Information
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CAS No. 2982511-19-1
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Molecular Weight 437.56
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Formula C24H32FN7
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SMILES
CN1CCC(NC2=C3C(N(C=C3)CCCN4CCCC4)=NC(C5=CC=NC(F)=C5)=N2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNMT1-IN-5 Related Classifications
HY-172217 Related Classifications
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