NSL1 - NSL1 component of MIS12 kinetochore complex Gene

Also Known as DC8; MIS14; C1orf48

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25936

About NSL1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,726,153-212,791,777 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 2.0), lymph node (RPKM 1.8) and 25 other tissues.

Summary

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]

NSL1 Products (5)

mRNA Protein Name
NM_001042549.2 NP_001036014.1 kinetochore-associated protein NSL1 homolog isoform 2
NM_001297736.2 NP_001284665.1 kinetochore-associated protein NSL1 homolog isoform 3
NM_001297737.2 NP_001284666.1 kinetochore-associated protein NSL1 homolog isoform 4
NM_001297739.2 NP_001284668.1 kinetochore-associated protein NSL1 homolog isoform 5
NM_015471.4 NP_056286.3 kinetochore-associated protein NSL1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15502821 GOA
Cellular Component GO Annotation Evidence References Source
part of MIS12/MIND type complex IDA
IDA: Inferred from direct assay
16585270 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
15371340 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
24530301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSL1 Protein Structure

Mis14

Mis14: Kinetochore protein Mis14 like (67 - 211)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

kinetochore-associated protein NSL1 homolog

  • NSL1, MIND kinetochore complex component, homolog

NSL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NSL1 Q96IY1 DSN1 Homo sapiens Q9H410
Lumier
37398436
Intra
NSL1 Q96IY1 DSN1 Homo sapiens Q9H410
BRET
37398436
Intra
NSL1 Q96IY1 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
33961781
Intra
NSL1 Q96IY1 DSN1 Homo sapiens Q9H410
Anti Tag CoIP
28514442
Intra
NSL1 Q96IY1 DSN1 Homo sapiens Q9H410
BiLC
37398436
Intra
NSL1 Q96IY1 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
NSL1 Q96IY1 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
NSL1 Q96IY1 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Osteosarcoma

  • Osteogenic Sarcoma Of Breast

  • Breast Extraskeletal Osteosarcoma
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Parasitic Protozoa Infectious Disease

  • Protozoan Infections

  • Mastigophora Infectious Disease

  • Sarcomastigophora Infectious Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07067 KANSL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09595 NSL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NSL1 VGNC VGNC:32277
Felis catus NSL1 VGNC VGNC:63889
Canis familiaris NSL1 VGNC VGNC:43986
Rattus norvegicus NSL1 RGD RGD:1562052
Macaca mulatta NSL1 VGNC VGNC:75454
Mus musculus NSL1 MGD MGI:2685830
Others NSL1 NCBI