EXD3 - exonuclease 3'-5' domain containing 3 Gene

Also Known as Nbr; mut-7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54932

About EXD3

This gene has 12 transcripts (splice variants), 165 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 2.6), fat (RPKM 2.4) and 25 other tissues.

Summary

Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. [provided by Alliance of Genome Resources, Apr 2022]

EXD3 Products (2)

mRNA Protein Name
NM_001286823.2 NP_001273752.1 exonuclease mut-7 homolog isoform b
NM_017820.5 NP_060290.3 exonuclease mut-7 homolog isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXD3 Protein Structure

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (390 - 567)

Mut7-C

Mut7-C: Mut7-C RNAse domain (631 - 744)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 876 a.a.
Protein Preferred Names Protein Names

exonuclease mut-7 homolog

  • exonuclease 3'-5' domain-containing protein 3

EXD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXD3 Q8N9H8 DAZAP2 Homo sapiens Q15038
Y2H Array
19060904
Intra
EXD3 Q8N9H8 DAZAP2 Homo sapiens Q15038
Y2H Pooling
19060904
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Atrial Septal Defect 8

  • ASD8

  • Atrial Heart Septal Defect 8

  • Septal Defect, Atrial, Type 8
Vulto-Van Silfhout-De Vries Syndrome

  • Vulto-Van Silfout-De Vries Syndrome

  • VSVS

  • Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures

  • Iddisbas

  • Mrd24

  • Mental Retardation, Autosomal Dominant 24

  • Autosomal Dominant Mental Retardation 24

  • Autosomal Dominant Non-Syndromic Intellectual Disability 24

  • Mental Retardation, Autosomal Dominant, Type 24
Atrial Septal Defect 4

  • ASD4

  • Atrial Heart Septal Defect 4

  • Septal Defect, Atrial, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04584 EXD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown