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RAP2A - RAP2A, member of RAS oncogene family Gene

Also Known as KREV; RAP2; K-REV; RbBP-30

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5911

About RAP2A

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:97,434,169-97,469,128 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues.

Summary

Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin Cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAP2A Products (1)

mRNA	Protein	Name
NM_021033.7	NP_066361.1	ras-related protein Rap-2a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IMP IMP: Inferred from mutant phenotype	9312017	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	22797597	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	9312017	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	1900290	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	9312017	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14966141	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15342639	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	22797597	GOA
NOT involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22797597	GOA
acts upstream of or within establishment of protein localization	IDA IDA: Inferred from direct assay	19061864	GOA
involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	15342639	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein localization	IDA IDA: Inferred from direct assay	15342639	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	14966141	GOA
involved in regulation of dendrite morphogenesis	IDA IDA: Inferred from direct assay	20159449	GOA
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	15953419	GOA
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	15953419	GOA
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	30063210	GOA
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	30063210	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	15953419	GOA
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	15953419	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22797597	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	19061864	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	19061864	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP2A Protein Structure

Ras

0
100
183 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rap-2a	RAP2, member of RAS oncogene family (K-rev)

RAP2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAP2A	P10114	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	32296183
Intra	RAP2A	P10114	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	32296183
Intra	RAP2A	P10114	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	32296183
Intra	RAP2A	P10114	MINK1	Homo sapiens	Q8N4C8	Anti Tag CoIP	33961781
Intra	RAP2A	P10114	RGL1	Homo sapiens	Q9NZL6-2	Y2H Array	32296183
Intra	RAP2A	P10114	RGL1	Homo sapiens	Q9NZL6-2	Y2H Prey Pooling	32296183
Intra	RAP2A	P10114	RGL1	Homo sapiens	Q9NZL6-2	Validated Y2H	32296183
Intra	RAP2A	P10114	EMP3	Homo sapiens	P54852	PLA	30614533
Intra	RAP2A	P10114	EMP3	Homo sapiens	P54852	BiFC	30614533

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11657	RAP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAP2A	VGNC	VGNC:33719
Mus musculus	RAP2A	MGD	MGI:97855
Felis catus	RAP2A	VGNC	VGNC:102303
Rattus norvegicus	RAP2A	RGD	RGD:620590
Canis familiaris	RAP2A	VGNC	VGNC:45344
Macaca mulatta	RAP2A	VGNC	VGNC:106288
Others	RAP2A	NCBI