TRAF7 - TNF receptor associated factor 7 Gene

Also Known as RFWD1; RNF119; CAFDADD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84231

About TRAF7

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,155,782-2,178,129 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues, 14 paralogues and is associated with 100 phenotypes. Ubiquitous expression in duodenum (RPKM 19.0), esophagus (RPKM 17.7) and 25 other tissues.

Summary

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF Receptor Superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

TRAF7 Products (1)

mRNA	Protein	Name
NM_032271.3	NP_115647.2	E3 ubiquitin-protein ligase TRAF7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21518757	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14743216	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	15001576	GOA
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15001576	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	14743216	GOA
involved in positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15001576	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21518757	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	21518757	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14743216	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	29961569	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF7 Protein Structure

zf-C3HC4_2

zf-TRAF

WD40

0
200
400
600
670 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRAF7	RING finger and WD repeat-containing protein 1

TRAF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	TRAF7	Q6Q0C0	Ripk4	Mus musculus	Q9ERK0	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiac, Facial, And Digital Anomalies With Developmental Delay	CAFDADD
Traf7-Associated Heart Defect-Digital Anomalies-Facial Dysmorphism-Motor And Speech Delay Syndrome
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Skull Base Meningioma	Meningioma Of The Skull Base
Skull Base Cancer	Tumors Of Skull Base Skull Base Neoplasms
Adenomatoid Tumor	Adenomatoid Tumour Benign Localised Epithelial Mesothelioma Benign Localized Epithelial Mesothelioma
Anterior Cranial Fossa Meningioma	Meningioma Of The Anterior Fossa
Olfactory Groove Meningioma	Meningioma Of The Olfactory Groove
Angiomatous Meningioma
Intraneural Perineurioma
Meningothelial Meningioma	Meningotheliomatous Meningioma
Secretory Meningioma	Meningioma
Chordoid Meningioma	Meningioma, Chordoid
Transitional Meningioma	Transitional Meningioma
Intraventricular Meningioma
Clear Cell Meningioma
Sphenoorbital Meningioma
Brain Meningioma	Intracranial Meningioma
Cerebral Convexity Meningioma	Cerebral Hemispheric Convexity Meningioma
Childhood Meningioma	Pediatric Meningioma
Rhabdoid Meningioma	Papillary Meningioma Meningioma, Rhabdoid
Foramen Magnum Meningioma	Meningioma Of The Foramen Magnum
Cerebral Falx Meningioma	Falcine Meningioma Falx Cerebri Meningioma
Spinal Meningioma	Spinal Cord Meningioma Meningioma, Spine Meningioma Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Intracranial Meningioma	Meningioma
Psammomatous Meningioma
Fibrous Meningioma	Fibroblastic Meningioma
Parasagittal Meningioma
Cavernous Sinus Meningioma	Meningioma Of The Cavernous Sinus
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Microcystic Meningioma
Tuberculum Sellae Meningioma	Meningioma Of The Tuberculum Sellae
Sella Turcica Neoplasm	Tumor Of Sella Turcica
Petroclival Meningioma
Benign Meningioma	Meningioma, Benign
Cerebral Meningioma	Meningioma Of Cerebrum
Optic Nerve Sheath Meningioma	Meningioma Of Optic Nerve Sheath
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Spinal Cancer	Spinal Cord Neoplasm Spinal Cord Neoplasms Spinal Neoplasms Intraspinal Tumor Malignant Tumor Of The Spinal Cord Spinal Cord Cancer Spinal Neoplasm Tumor Of The Spinal Cord Tumors Spinal Cord Intraspinal Neoplasm Spinal Cord--Cancer
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14976	TRAF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20502	Traf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27010	Traf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRAF7	VGNC	VGNC:66502
Rattus norvegicus	TRAF7	RGD	RGD:1559653
Canis familiaris	TRAF7	VGNC	VGNC:47770
Bos taurus	TRAF7	VGNC	VGNC:36279
Macaca mulatta	TRAF7	VGNC	VGNC:79252
Mus musculus	TRAF7	MGD	MGI:3042141
Others	TRAF7	NCBI