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Cat. No.: HY-134217

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KYN-101

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.

For research use only. We do not sell to patients.

Purity: 98.03%
CAS No.: 2247950-73-6
Formula: C₂₂H₁₉FN₆
Molecular Weight:386.42

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

KYN-101 Chemical Structure

CAS No.: 2247950-73-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity^[1].

In Vitro

KYN-101 (0.5, 1 µM; 24 h) decreases the CYP1A1 mRNA expression in IDO^high samples^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KYN-101 (10 mg/kg; p.o.; daily for 12 days) shows anti-cancer activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)^[1]
Dosage:

10 mg/kg
Administration:

P.o.; daily for 12 days
Result:

Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.

Chemical Information

CAS No. 2247950-73-6
Appearance Solid
Molecular Weight 386.42
Formula C₂₂H₁₉FN₆
Color Off-white to light yellow
SMILES

CC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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bioRxiv

2026 Jun 22.
bioRxiv

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening. [Abstract]

2026 May 8:2026.05.07.723570. PMID: 42146571

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (258.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5879 mL

12.9393 mL

25.8786 mL

5 mM

0.5176 mL

2.5879 mL

5.1757 mL

10 mM

0.2588 mL

1.2939 mL

2.5879 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5879 mL	12.9393 mL	25.8786 mL	64.6964 mL
	5 mM	0.5176 mL	2.5879 mL	5.1757 mL	12.9393 mL
	10 mM	0.2588 mL	1.2939 mL	2.5879 mL	6.4696 mL
	15 mM	0.1725 mL	0.8626 mL	1.7252 mL	4.3131 mL
	20 mM	0.1294 mL	0.6470 mL	1.2939 mL	3.2348 mL
	25 mM	0.1035 mL	0.5176 mL	1.0351 mL	2.5879 mL
	30 mM	0.0863 mL	0.4313 mL	0.8626 mL	2.1565 mL
	40 mM	0.0647 mL	0.3235 mL	0.6470 mL	1.6174 mL
	50 mM	0.0518 mL	0.2588 mL	0.5176 mL	1.2939 mL
	60 mM	0.0431 mL	0.2157 mL	0.4313 mL	1.0783 mL
	80 mM	0.0323 mL	0.1617 mL	0.3235 mL	0.8087 mL
	100 mM	0.0259 mL	0.1294 mL	0.2588 mL	0.6470 mL

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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KYN-101

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) KYN-101

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

KYN-101

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) KYN-101

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

KYN-101 Related Classifications

HY-134217 Related Classifications