Mycothiazole
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans.
For research use only. We do not sell to patients.
- CAS No.: 114582-75-1
- Formula: C22H32N2O3S
- Molecular Weight:404.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.35 nM
Compound: 1
|
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
|
[PMID: 32071675] |
| HepG2 | IC50 |
0.27 nM
Compound: 1
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
|
[PMID: 32071675] |
| PANC-1 | IC50 |
0.16 nM
Compound: 1
|
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay
|
[PMID: 32071675] |
Chemical Information
-
CAS No. 114582-75-1
-
Molecular Weight 404.57
-
Formula C22H32N2O3S
-
SMILES
COC(NCCC(/C=C\C[C@H](O)C(C)(C1=NC(C/C=C\CC=C)=CS1)C)=C)=O
-
Structure Classification
-
Initial Source
marine sponge
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mycothiazole Related Classifications
HY-N12887 Related Classifications
Powered by Bioz