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Cat. No.: HY-W714201

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Nitralin

Nitralin is a dinitroaniline herbicide. Nitralin exhibits inhibitory activity against Cryptosporidium parvum, with a IC₅₀ of 4.5 µM.

For research use only. We do not sell to patients.

CAS No.: 4726-14-1
Formula: C₁₃H₁₉N₃O₆S
Molecular Weight:345.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nitralin Chemical Structure

CAS No.: 4726-14-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Nitralin is a dinitroaniline herbicide. Nitralin exhibits inhibitory activity against Cryptosporidium parvum, with a IC₅₀ of 4.5 µM^[1]^[2].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	0.5 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.6 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.8 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	19.2 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.1 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	23.9 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	3.7 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	30.3 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	31.3 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	4.3 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	4.9 μM Compound: 9	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]

In Vitro

Nitralin significantly inhibits Cryptosporidium parvum growth in the Madin Darby canine kidney (MDCK) cell in vitro cultivation model with an IC₅₀ of 4.5 µM, with no observed toxicity^[1].
Nitralin (25-50 μg/mL) stimulates the growth rate of Pseudomonas fluorescens by 22.0% at 25 μg/mL, while having no significant effect on the growth rates of Erwinia carotovora or Bacillus sp. at 50 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 4726-14-1
Molecular Weight 345.37
Formula C₁₃H₁₉N₃O₆S
SMILES

CCCN(CCC)C1=C(C=C(S(=O)(C)=O)C=C1[N+]([O-])=O)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Arrowood MJ, et al. In vitro anticryptosporidial activity of dinitroaniline herbicides. FEMS Microbiol Lett. 1996 Mar 1;136(3):245-9.
[Content Brief]

[2]. Breazeale FW, Camper ND. Effect of selected herbicides on bacterial growth rates. Appl Microbiol. 1972 Feb;23(2):431-2.
[Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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