IL-20
Interleukin-20 (IL-20) is an IL-10 family cytokine discovered through keratinocyte psoriasis models; it is secreted by monocytes, macrophages and keratinocytes and signals via two distinct receptor complexes, IL-20Rα/IL-20Rβ and IL-22Rα1/IL-20Rβ, converging on STAT3 activation. IL-20 acts preferentially on skin and mucosal tissues: it promotes keratinocyte proliferation, angiogenesis and the production of antimicrobial peptides and chemokines such as CXCL8, contributing to epidermal acanthosis and parakeratosis seen in psoriasis. In contrast to its inflammatory role in skin, IL-20 exerts protective effects in other contexts-it supports osteoblast differentiation, attenuates renal ischemia-reperfusion injury and colitis, and modulates hepatocyte regeneration. Its receptors are upregulated in psoriatic lesions, inflammatory bowel disease and rheumatoid arthritis synovium, making the IL-20 axis a therapeutic consideration in inflammatory skin and joint diseases.
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IL-20 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
