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Cat. No.: HY-149776

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RGH-560

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice.

For research use only. We do not sell to patients.

CAS No.: 2408799-43-7
Formula: C₂₂H₂₀FN₃O₃
Molecular Weight:393.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

RGH-560 Chemical Structure

CAS No.: 2408799-43-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg; Intraperitoneal injection) has significant cognitive-enhancement in Scopolamine(HY-N0296)-induced amnesia in mice. RGH-560 is a medium clearance compound. RGH-560 is non-toxic to mice at doses up to 30 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with scopolamine-induced amnesia^[1]
Dosage:

1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Reversed the scopolamine-induced cognitive impairment.

Chemical Information

CAS No. 2408799-43-7
Molecular Weight 393.41
Formula C₂₂H₂₀FN₃O₃
SMILES

CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560). Journal of Medicinal Chemistry. 2023 Nov. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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