3-Heptadecylcatechol
3-Heptadecylcatechol is an urushiphenol compound found in Toxicodendron vernicifluum resin and poison oak urushiol. 3-Heptadecylcatechol exhibits anti-platelet aggregation and immune regulation activity. 3-Heptadecylcatechol can be used for the research of thrombotic disorders.
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- CAS No.: 5862-27-1
- Formule: C23H40O2
- Masse moléculaire:348.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
3-Heptadecylcatechol (5 min) inhibits ADP-induced rabbit platelet aggregation with an IC50 of 7.67 μmol/L and AA-induced rabbit platelet aggregation with an IC50 of 6.04 μmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (male or female, 6-10 weeks)[2]
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Dosage:2.5 mg (abdominal cutaneous application); 50 μg (ear cutaneous application)
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Administration:cutaneous application; single dose
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Result:Induced draining inguinal lymph node cell (LNC) proliferation that peaked 5-6 days post-abdominal treatment, while distal cervical LNC showed minimal proliferation.
Induced cervical LNC proliferation that peaked 5 days post-ear treatment; prior abdominal sensitization strongly suppressed this cervical LNC proliferation.
Induced suppressive activity against recipient LNC proliferation starting 7 days post-sensitization, with up to 58% suppression observed 10 days post-sensitization.
Showed both specific and non-specific components: suppression of homologous-induced proliferation was significantly stronger than suppression of OX-induced proliferation.
Completely abrogated suppressive activity when sensitized LNC were treated with anti-Thy-1.2 antibody plus complement, confirming suppressor cells are T lymphocytes.
Did not suppress the in vitro proliferation of optimally activated day-6 sensitized LNC.
Did not affect the induction of contact sensitivity, as ear swelling responses post-challenge were equivalent between recipients of sensitized LNC and normal LNC.
Chemical Information
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CAS No. 5862-27-1
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Masse moléculaire 348.56
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Formule C23H40O2
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SMILES
OC1=CC=CC(CCCCCCCCCCCCCCCCC)=C1O
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Xie Y, et al. New urushiols with platelet aggregation inhibitory activities from resin of Toxicodendron vernicifluum. Fitoterapia. 2016;112:38-44. [Content Brief]
[2]. Dunn IS, et al. Induction of suppressor T cells for lymph node cell proliferation after contact sensitization of mice with a poison oak urushiol component. Immunology. 1984 Apr;51(4):773-81. [Content Brief]
[3]. Dunn IS, et al. Influence of chemical reactivity of urushiol-type haptens on sensitization and the induction of tolerance. Cell Immunol. 1986 Jan;97(1):189-96. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Heptadecylcatechol Related Classifications
HY-N19844 Related Classifications
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