3-Hydroxypropionyl-CoA
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3-Hydroxypropionyl-CoA is a metabolic intermediate and enzyme substrate/product that functions in multiple metabolic pathways. 3-Hydroxypropionyl-CoA serves as a substrate for 3-Hydroxypropionyl-CoA dehydratase (HY-E71752), a product of 3-hydroxypropionyl-CoA synthetase, and a hydrolysis substrate for Ehd3p. 3-Hydroxypropionyl-CoA participates in autotrophic CO2 fixation, modified β-oxidation, and reverse hydration reactions. Accumulation of 3-Hydroxypropionyl-CoA inhibits fatty acid β-oxidation at the Fox2p site and induces metabolic toxicity. 3-Hydroxypropionyl-CoA can be used in studies of hematogenously disseminated candidiasis.
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- Pureté : 91.16%
- CAS No.: 157786-88-4
- Formule: C24H40N7O18P3S
- Masse moléculaire:839.60
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Stockage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
3-Hydroxypropionyl-CoA acts as a substrate for recombinant 3-Hydroxypropionyl-CoA dehydratase (HY-E71752) from Metallosphaera sedula, which catalyzes its dehydration to acryloyl-CoA with an apparent Km of 60 μM[1].
3-Hydroxypropionyl-CoA causes Candida albicans SC5314 cells to show complete growth inhibition on butyrate/propionate medium when accumulated (due to Ehd3p deletion), demonstrating that this metabolite potently and specifically inhibits fatty acid β-oxidation[2].
3-Hydroxypropanoyl-CoA is identified as a minor synthetic side product of 4-nitrobutyryl-CoA production and a degradation product of the human GCD-catalyzed oxidation of 4-nitrobutyryl-CoA, detected via mass spectrometry with distinct m/z values and intensities depending on the electron acceptor used[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 157786-88-4
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Appearance Solid
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Masse moléculaire 839.60
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Formule C24H40N7O18P3S
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CCO)=O)=O)=O)O)C)=O)=O)O3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvant et solubilité
In Vitro:
H2O : ≥ 20 mg/mL (23.82 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1910 mL | 5.9552 mL | 11.9104 mL | 29.7761 mL |
| 5 mM | 0.2382 mL | 1.1910 mL | 2.3821 mL | 5.9552 mL | |
| 10 mM | 0.1191 mL | 0.5955 mL | 1.1910 mL | 2.9776 mL | |
| 15 mM | 0.0794 mL | 0.3970 mL | 0.7940 mL | 1.9851 mL | |
| 20 mM | 0.0596 mL | 0.2978 mL | 0.5955 mL | 1.4888 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Hydroxypropionyl-CoA Related Classifications
HY-E70241 Related Classifications
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Keywords
- 3-Hydroxypropionyl-CoA
- 157786-88-4
- Endogenous Metabolite
- Fungal
- 3-hydroxypropionyl-CoA dehydratase
- fatty acid β-oxidation
- hematogenously disseminated candidiasis
- Candida albicans SC5314
- Ehd3p
- Fox2p
- acryloyl-CoA reductase
- Metallosphaera sedula
- autotrophic CO2 fixation
- 3-hydroxypropionyl-CoA synthetase
- Inhibitor
- inhibitor
- inhibit