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Cat. No.: HY-111369

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CHK1-IN-2

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM.

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CAS No.: 912367-45-4
Formule: C₂₀H₂₂N₄OS
Masse moléculaire:366.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CHK1-IN-2 Chemical Structure

CAS No.: 912367-45-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM.

IC₅₀ & Target^[1]

Chk1

6 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Checkpoint Kinase (Chk) :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	GI₅₀	306 nM Compound: 44	Antiproliferative activity against human MDA-MB-231 cells Antiproliferative activity against human MDA-MB-231 cells	[PMID: 29301085]
NCI-H460	GI₅₀	2453 nM Compound: 44	Antiproliferative activity against human H460 cells harboring dominant negative p53 construct Antiproliferative activity against human H460 cells harboring dominant negative p53 construct	[PMID: 29301085]
SW-620	GI₅₀	725 nM Compound: 44	Antiproliferative activity against human SW620 cells Antiproliferative activity against human SW620 cells	[PMID: 29301085]

In Vitro

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 912367-45-4
Masse moléculaire 366.48
Formule C₂₀H₂₂N₄OS
SMILES

O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yang B, et al. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem. 2018 Feb 8;61(3):1061-1073. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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CHK1-IN-2

Voir tous les produits spécifiques à Isoform Checkpoint Kinase (Chk)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CHK1-IN-2 Related Classifications

HY-111369 Related Classifications