FK-448 Free base
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 85858-76-0
- Formule: C25H30N2O3
- Masse moléculaire:406.52
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-13821
EpoxomicinProteasome Inhibitor -
HY-13207
ONX-0914Proteasome Inhibitor -
HY-10454
DelanzomibProteasome Inhibitor -
HY-110404
CapziminRpn11 Inhibitor -
HY-100739
RA190RPN13 Inhibitor -
HY-12286
PI-1840CT-L Inhibitor -
HY-18236
MDL-28170Calpain Inhibitor -
HY-18964
MG-101Cysteine Protease Inhibitor -
HY-100529
PD150606Calpain Inhibitor -
HY-16594
LactacystinProteasome Inhibitor -
HY-13259C
(R)-MG-132Proteasome Inhibitor -
HY-N2306
Aclacinomycin ATopoisomerase Inhibitor
Activité biologique
Description
IC50 & Target
IC50: 720 nM (Chymotrypsin)[1]
In Vitro
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM[1]. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 85858-76-0
-
Masse moléculaire 406.52
-
Formule C25H30N2O3
-
SMILES
O=C(C1CCCC2=C1C=CC=C2)OC3=CC=C(C(N4CCN(C(C)C)CC4)=O)C=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Fujii S, et al. New synthetic inhibitors of chymotrypsin. J Biochem. 1984 Feb;95(2):319-22. [Content Brief]
[2]. Fujii S, et al. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37(8):545-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FK-448 Free base Related Classifications
HY-100193 Related Classifications
Powered by Bioz