Tritoqualine
Tritoqualine is a histidine decarboxylase inhibitor, that inhibits the release of histidine.
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- CAS No.: 14504-73-5
- Formule: C26H32N2O8
- Masse moléculaire:500.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
histidine decarboxylase[1]
In Vitro
The effect of Tritoqualine (TRQ) on the CCl4-induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl4. Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl4-stimulated lipid peroxidation at a concentration of 33 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14504-73-5
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Masse moléculaire 500.54
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Formule C26H32N2O8
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SMILES
O=C1OC(C2N(C)CCC3=C2C(OC)=C(OCO4)C4=C3)C5=C1C(N)=C(OCC)C(OCC)=C5OCC
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Synonyms
Inhibostamin; Hypostamine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ishii K, et al. Therapeutic effect of histidine decarboxylase inhibitor on chronic active hepatitis. Gastroenterol Jpn. 1978;13(2):105-10. [Content Brief]
[2]. Yuasa S, et al. Suppressive effect of tritoqualine on lipid peroxidation and enzyme leakage induced by carbon tetrachloride in rat hepatocytes. Jpn J Pharmacol. 1986 Jun;41(2):205-10. [Content Brief]
[3]. Umezu K, et al. Inhibitory effect of tritoqualine (TRQ) on histamine release from mast cells. Jpn J Pharmacol. 1985 Jun;38(2):153-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tritoqualine Related Classifications
HY-U00065 Related Classifications
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