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Cat. No.: HY-W1142093

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ActRIIB-IN-4

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice.

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CAS No.: 3039974-41-6
Formule: C₂₂H₂₃N₅O₂
Masse moléculaire:389.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-4 Chemical Structure

CAS No.: 3039974-41-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice^[1].

Voir tous les produits spécifiques à Isoform TGF-β Receptor :

In Vitro

ActRIIB-IN-4 (0.625-10 μM) exerts a significant reversing effect on C2C12 myotube atrophy, with a reversal rate of 100.3% at 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-4 (10 mg/kg; i.p.) significantly enhances muscle grip strength in C26 tumor cachexia mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3039974-41-6
Masse moléculaire 389.45
Formule C₂₂H₂₃N₅O₂
SMILES

C1(C2=CC=C(OCCN3CCOCC3)C=C2)=CN=C(NC=C4C5=NNC=C5)C4=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661A1. WIPO (PCT). 2023-11-29.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
- In Vivo
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Pureté et documentation
Références

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ActRIIB-IN-4

Voir tous les produits spécifiques à Isoform TGF-β Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ActRIIB-IN-4 Related Classifications

HY-W1142093 Related Classifications