Agathic acid
Agathic acid is an orally active diterpenoid resin acid that can be isolated from coniferous plants such as Agathis and Araucaria. Agathic acid exhibits anti-inflammatory, antibacterial, antioxidant, and antitumor activities. Agathic acid can be used in research on bacterial infections, inflammation, and cancer.
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- CAS No.: 640-28-8
- Formule: C20H30O4
- Masse moléculaire:334.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
Leishmania 28.0 μg/mL (IC50, Promastigote) |
Leishmania 17.0 μg/mL (IC50, Amastigote) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Erythrocyte | CC50 |
350 μg/mL
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Cytotoxicity against human erythrocytes incubated for 3 hrs, assessed via measurement of supernatant absorbance at 550 nm to calculate haemolysis percentage.
Cytotoxicity against human erythrocytes incubated for 3 hrs, assessed via measurement of supernatant absorbance at 550 nm to calculate haemolysis percentage.
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23440116 |
In Vitro
Agathic acid exhibits no activity against A2780 cells within the tested dose range[1].
Agathic acid (72 h) inhibits the proliferation of Leishmania amazonensis promastigotes and amastigotes, with IC50 values of 28.0 μg/mL and 17.0 μg/mL, respectively[2].
Agathic acid (100 μg/mL; 3 h) significantly increases the plasma membrane permeability of in vitro-cultured Leishmania amazonensis amastigotes, with 63.4% of cells showing positive Propidium Iodide (HY-D0815) uptake. It also induces mitochondrial membrane potential depolarization, reducing the proportion of the cell population with Rhodamine 123 (HY-D0816) fluorescence to 27.5%[2].
Agathic acid (3 h) exhibits a CC50 of 350 μg/mL in human erythrocytes, with a selectivity index of 20.6 against Leishmania amazonensis amastigotes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leishmania amazonensis
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Concentration:100 μg/mL
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Incubation Time:3 h
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Result:Potently inhibited the activity of the parasites and 63.4% of the cells tested positive for Propidium Iodide uptake.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mixed-breed beef cows (healthy, experimentally naïve, 465-650 kg, late-term pregnant)[3]
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Dosage:102 mg/kg; 134 mg/kg; 144 mg/kg
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Administration:p.o.; twice daily; until abortion
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Result:Induced abortion in treated cows after 6, 5, and 4 days of treatment, respectively.
Showed a dose-response relationship where higher daily doses correlated with fewer days to abortion.
Detected agathic acid, dihydroagathic acid, and tetrahydroagathic acid in serum samples, with higher serum concentrations of agathic and dihydroagathic acid in cows that aborted earlier.
Chemical Information
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CAS No. 640-28-8
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Masse moléculaire 334.45
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Formule C20H30O4
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SMILES
O=C([C@@]1(C)CCC[C@]2(C)[C@@H](CC/C(C)=C/C(O)=O)C(CC[C@@]12[H])=C)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Agathic acid Related Classifications
HY-126465 Related Classifications
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Keywords
- Agathic acid
- 640-28-8
- Endogenous Metabolite
- Parasite
- Bionectria sp
- Copaifera oleoresins
- human erythrocytes
- human ovarian cancer cell line A2780
- Juniperus osteosperma bark
- Leishmania amazonensis amastigotes
- mitochondrial membrane depolarisation
- leishmaniasis
- Leishmania amazonensis promastigotes
- late-term pregnant cattle
- Inhibitor
- inhibitor
- inhibit