AK-42
AK-42 is a selective CLC-2 chloride channel inhibitor with human IC50 of 17 nM and rat IC50 of 14 nM. AK-42 binds to an extracellular vestibule above the channel pore, inhibits CLC-2 currents acutely and reversibly, including with auxiliary subunit GlialCAM coexpression. AK-42 acts as a selective tool compound for acute CLC-2 function modulation to probe CLC-2 neurophysiology. AK-42 can be used for the research of leukodystrophy and idiopathic generalized epilepsies.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 15437-29-3
- Formule: C20H15Cl2NO3
- Masse moléculaire:388.24
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CLC-2 14 (rat) nM (IC50) |
CLC-2 17 (human) nM (IC50) |
In Vitro
AK-42 (5 min) potently inhibits human CLC-2 chloride currents stably expressed in CHO cells with an IC50 of 17 nM, and displays >1000-fold selectivity over CLC-1 with minimal off-target activity against other CNS membrane proteins and anion channels[1].
AK-42 potently and reversibly inhibits rat CLC-2 chloride currents transiently expressed in CHO cells with an IC50 of 14 nM, with comparable efficacy against CLC-2 coexpressed with GlialCAM, and its binding is dependent on specific extracellular channel residues including K210 and Q399[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 15437-29-3
-
Masse moléculaire 388.24
-
Formule C20H15Cl2NO3
-
SMILES
O=C(C1=C(NC2=C(Cl)C(OCC3=CC=CC=C3)=CC=C2Cl)C=CC=C1)O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AK-42 Related Classifications
HY-182571 Related Classifications
Powered by Bioz