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Cat. No.: HY-148684

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AMPK activator 10

AMPK activator 10 is an orally active, potent AMPK activator with EC₁₅₀ of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect.

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CAS No.: 1914176-03-6
Formule: C₂₄H₂₆ClFN₄O₆
Masse moléculaire:520.94

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AMPK activator 10 Chemical Structure

CAS No.: 1914176-03-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

AMPK

Voir tous les produits spécifiques à Isoform AMPK :

In Vivo

AMPK activator 10 (compound 14d; 0.3, 1, 3 mg/kg; Orally; bid; for 21 days) exhibits a glucose lowering effect^[1].
AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; orally; single dose) leads to increase in the phosphorylation levels of ACC, which is a downstream target molecule of AMPK, in a dose-dependent manner^[1].
AMPK activator 10 (0.5 mg/kg by iv or 1.0 mg/kg by po) has a CL of 9.02 mL/min•kg, a C_max of 65.4 ng/mL and an AUC of 347 ng•h/mL for rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KKAy mice^[1]
Dosage:

0.3, 1, 3 mg/kg
Administration:

Orally; bid; for 21 days
Result:

Exhibited a glucose lowering effect.
The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group.

Animal Model:

Rats^[1]
Dosage:

0.5 mg/kg by iv or 1.0 mg/kg by po
Administration:

IV or po
Result:

Had a CL of 9.02 mL/min•kg, a C_max of 65.4 ng/mL and an AUC of 347 ng•h/mL.

Chemical Information

CAS No. 1914176-03-6
Masse moléculaire 520.94
Formule C₂₄H₂₆ClFN₄O₆
SMILES

COCCOC1=CC(F)=C(C(CC2)=C1)[C@H]2NC3=C(Cl)C=C(NC(O[C@H]4[C@]5([H])[C@]([C@@H](CO5)O)([H])OC4)=N6)C6=N3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yuusuke Tamura, et al. Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles. Bioorg Med Chem Lett. 2023 Jan 1;79:129059. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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AMPK activator 10

Voir tous les produits spécifiques à Isoform AMPK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AMPK activator 10 Related Classifications

HY-148684 Related Classifications