Antimicrobial agent-7
Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.
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- Formule: C36H56N24
- Masse moléculaire:824.99
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Antimicrobial agent-7 (2.8-56.4 μM; 24 h) inhibits Gram-negative bacteria and Gram-positive bacteria growth[1].
Antimicrobial agent-7 (5 and 20 μg/mL; 18 h) inhibits the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) by lipopolysaccharide-stimulated in RAW 264.7 cells[1].
Antimicrobial agent-7 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-7 displays synergistic or additive effects when combined with selected clinically used antibiotics[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
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Concentration:2.8-56.4 μM
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Incubation Time:24 hours
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Result:Inhibited Gram-negative bacteria with MIC values of 17.7 and 4.8 μM for E. coli [KCTC 1682] and P. aeruginosa [KCTC 1637], respectively.
Inhibited Gram- positive bacteria with MIC values of 4.8 μM for S. epidermidis [KCTC 1917] and S. aureus [KCTC1621].
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Cell Line:RAW 264.7 macrophages
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Concentration:5 and 20 μg/mL
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Incubation Time:18 hours
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Result:Observed LPS-stimulated production of NO with an inhibitory rate of 68.09% at 5 μg/mL.
Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 99.83% at 20 μg/mL.
Chemical Information
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Masse moléculaire 824.99
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Formule C36H56N24
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SMILES
NC(NCCNC1=NC(NCCNC(N)=N)=NC(N(C(CN2C3=NC(NCCNC(N)=N)=NC(NCCNC(N)=N)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1)=N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-7 Related Classifications
HY-151401 Related Classifications
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